Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics.

ABSTRACT: Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic-clonic seizures, focal seizures, status epilepticus, and pediatric epilepsy. However, the original research medicine of phenobarbital has not been launched in China. Therefore, an economical and effective generic medicine is of great significance to patients. In this study, a single-center, randomized, open-label, single-dose, two-formulation, two-period, two-sequence crossover design and parallel design were adopted. The phenobarbital tablets produced by Shandong Xinhua Pharmaceutical Co., Ltd. were used as the test for

SUBMITTER: Xinman W 

PROVIDER: S-EPMC12672406 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature