Neutrophils, not macrophages, aid phage-mediated control of pulmonary <i>Pseudomonas aeruginosa</i> infection.

ABSTRACT:

Background

The increasing prevalence of multidrug-resistant (MDR) bacteria has reduced the effectiveness of standard antibiotics, prompting renewed interest in bacteriophage (phage) therapy as an alternative or adjunctive treatment. Phage therapy offers high specificity, self-amplification at infection sites, and minimal disruption to the gut microbiota. However, clinical implementation is challenging, due to the risk of phage resistance and uncertainties regarding optimal dosing and immune interactions.

Methods

Previously, we demonstrated that a two-phage cocktail exhibited low immunogenicity in mice and, when combined with meropenem, significantly improved clearance of ventilator-associated Pseudomonas aeruginosa pneumonia, reduced inflammation, and disrupted biofil

SUBMITTER: Weissfuss C 

PROVIDER: S-EPMC12672430 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature