Comprehensive analysis of the role of diverse programmed cell death patterns in sepsis.

ABSTRACT:

Background

Sepsis, a life-threatening condition with persistently high mortality, involves dysregulated immune responses and programmed cell death (PCD). However, the specific roles and interactions of diverse PCD pathways in sepsis pathogenesis remain incompletely understood. This study aimed to systematically characterize PCD patterns and their clinical relevance in sepsis.

Methods

We integrated three bulk transcriptomic datasets (81 controls, 165 sepsis patients) and one single-cell RNA sequencing (scRNA-seq) dataset (4 controls, 4 early sepsis patients, 52,315 cells) from public databases. Gene set variation analysis (GSVA) quantified activity of 13 PCD pathways. Immune infiltration was assessed via single-sample gene set enrichment analysis (ssGSEA). A cell death-associ

SUBMITTER: Yu X 

PROVIDER: S-EPMC12672461 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature