Clinical and genomic characterization of <i>Klebsiella pneumoniae</i> in a district hospital in Chengdu, China.

ABSTRACT: Klebsiella pneumoniae is a significant human pathogen in both hospital and community settings; however, limited data exist regarding its prevalence in district-level hospitals. This study aimed to characterize the drug resistance mechanisms, molecular epidemiology, and virulence profiles of K. pneumoniae in a district hospital in Chengdu, China. A total of 114 clinical isolates were collected between May 2023 and May 2024. Antimicrobial susceptibility testing using the broth microdilution method revealed resistance rates of 14.0-21.1% to third-generation cephalosporins, and 5.3% to carbapenems. Whole-genome sequencing showed that 18.4% (21/114) of the isolates carried ESBL genes, with bla _CTX-M-15 (n = 7) being the most common. Six carbapenem-resistan

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12672463 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature