Loss of Nocturnin increases neuronal viability in oxidative stress conditions.

ABSTRACT: Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) and antioxidants, plays a critical role in neurodegenerative disorders like Parkinson's Disease (PD) and is strongly associated with neuronal cell death. Nocturnin was identified as a NADP(H) phosphatase and key regulator of oxidative stress. NADPH serves as a crucial co-factor for enzymes which regenerate antioxidants, and downregulation of its levels increases sensitivity to oxidative stress mediated neurodegeneration. In this study, we examined how the loss of Nocturnin impacts redox homeostasis and neuronal survival in Cath.a-differentiated (CAD) cells and dopaminergic neurodegeneration in a mutant alpha-synuclein overexpression PD mouse model (DA_SYN53). Here we demonstrate that loss of Noc

SUBMITTER: Ojo AE 

PROVIDER: S-EPMC12672471 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature