Antibiofilm sustainable strategies: pomegranate extract from agri-food waste as a natural antifungal against emerging <i>Candida</i> pathogens.

ABSTRACT:

Introduction

Candida spp. infections are a leading cause of morbidity, particularly among immunocompromised and hospitalized patients. Their pathogenicity is driven by multiple virulence factors, including dimorphic transitions, germ tube formation, and biofilm development. Biofilms enhance resistance to antifungal agents and immune defenses, making biofilm-associated Candida infections a significant clinical challenge. There is an urgent need for effective and sustainable therapies, with agri-food waste emerging as a promising source of bioactive compounds.

Methods

This in vitro study evaluated the antifungal activity of a polyphenol-rich hydroethanolic pomegranate (Punica granatum L.) peel extract against clinical isolates of Candida albicans, C. gl

SUBMITTER: Sateriale D 

PROVIDER: S-EPMC12672473 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature