Case Report: Acute generalized exanthematous pustulosis with psoriasis successfully treated with Secukinumab.

ABSTRACT:

Background

Acute generalized exanthematous pustulosis (AGEP) is a rare but severe cutaneous adverse reaction characterized by the abrupt onset of non-follicular sterile pustules on an erythematous and edematous background. These pustules typically appear within 24 to 48 hours after exposure to the causative drug, often localized to the face, trunk, and intertriginous area. Herein we firstly reported a 56-year-old man with severe plaque psoriasis who developed metamizole-induced AGEP during a clinical trial for BEBT-305 (HSP90 inhibitor) that was successfully treated with Secukinumab.

Case summary

A 56-year-old man with a 40-year history of severe plaque psoriasis developed fever and self-administered metamizole. Within a few days, a progressive eruption appeared and worsened

SUBMITTER: Zheng JN 

PROVIDER: S-EPMC12672486 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature