Case report of immune checkpoint inhibitor induced cholestatic hepatitis, acute renal injury and asymptomatic pancreatic enzyme elevation simultaneously.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have demonstrated promising antitumor activity. However, it may induce immune-related adverse events (irAEs). Multi-organ irAEs remain heterogeneous and incompletely characterized. We report a unique irAE pattern with synchronous hepatic, renal and pancreatic involvement which is first reported.

Case presentation

5 males developed a rare multi-organ irAE pattern with concurrent cholestatic hepatitis, renal injury and pancreatic enzyme elevation, representing 0.40% of the ICI-treated cohort. The syndrome showed early, rapidly onset and often began with nonspecific complaints requiring close monitoring.

Management

Responses of high dose glucocorticoid were varied by organs. Compared with renal and pancreatic injury, cholest

SUBMITTER: Jiao R 

PROVIDER: S-EPMC12672487 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature