Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses.

ABSTRACT:

Background

The four dengue virus serotypes (DENV1-4), Zika virus (ZIKV) and chikungunya virus (CHIKV) have similar epidemiology and transmission cycles and are the most prevalent arthropod-borne viruses in humans, with half the world's population at risk of infection. Although these infections share overlapping clinical presentations, the immune mechanisms that distinguish these infections, particularly in children, remain poorly defined. We aimed to characterize the immune responses to DENV, ZIKV, and CHIKV in a pediatric population and to define the specific immune signatures associated with each virus.

Methods

We characterized the immune responses to DENV, ZIKV and CHIKV by measuring cytokine/chemokine/growth-factor profiles in plasma/serum samples, and immune-cell profil

SUBMITTER: Tomalin LE 

PROVIDER: S-EPMC12672498 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature