Research trends in neoadjuvant therapy for esophageal cancer: a bibliometric and meta-analysis.

ABSTRACT:

Background

Neoadjuvant treatment followed by radical surgery has become the standard treatment approach for locally advanced esophageal cancer. We aimed to explore the development trends, research hotspots, and differences among treatment regimens in this field using bibliometric analysis and meta-analysis.

Methods

Literature on neoadjuvant therapy for esophageal cancer was retrieved from PubMed, Embase, Cochrane Library, and Web of Science. Bibliometric analysis and visualization were conducted on publications since 2000 from Web of Science Core Collection (WoSCC) using CiteSpace, VOSviewer, and the bibliometrix package in RStudio. A meta-analysis of phase III randomized controlled trials (RCTs) involving different treatment regimens was performed using Stata/MP, based on s

SUBMITTER: Wang H 

PROVIDER: S-EPMC12672519 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature