Pharmacogenomic landscape of TNF inhibitors in the Middle Eastern Qatari population.

ABSTRACT:

Introduction

Tumor necrosis factor alpha (TNF-α) is an important cytokine that frequently contributes to the pathogenicity of autoimmune diseases. Therefore, TNF inhibitors (TNFi) are used to treat autoimmune diseases. However, around 40% of the patients do not respond to TNFi, with genetic variants being a contributor to this variance. The prevalence of genetic variants affecting TNFi response in Middle Eastern populations is still not understood.

Methods

We assessed the distribution of variants in 111 genes associated with TNFi in 14,387 Qatari individuals using whole genome sequencing data.

Results

Of the 151 known pharmacogenomic variants associated with response to TNFi, approximately half have significantly different allele frequency distribution in the Qatari p

SUBMITTER: Jan Z 

PROVIDER: S-EPMC12672520 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature