CT predicts intraprocedural hemodynamics with computational fluid dynamics in TMVR-ineligible patients undergoing M-TEER.

ABSTRACT:

Background

Hemodynamic outcomes in patients undergoing transcatheter mitral edge-to-edge repair (M-TEER) are difficult to predict. Computational fluid dynamics (CFD) is frequently used in biomedical engineering to simulate blood flow patterns under various conditions.

Objectives

We developed a standardized workflow for individualized CFD analyses to predict postinterventional mitral valve gradients and residual regurgitation following TEER.

Methods

Twenty patients with severe mitral regurgitation (MR) from two high-volume centers underwent full-cycle cardiac computed tomography before intervention. Based on the specific valve morphology, individualized CFD simulations were performed to calculate MR volumes prior to intervention and estimate hemodynamics after M-TEER.<

SUBMITTER: Kirchner J 

PROVIDER: S-EPMC12672551 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature