Antimicrobial activity and antifungal mechanistic study of 3‑substituted oxindoles against Aspergillus niger.

ABSTRACT: A series of 3-substituted oxindole derivatives 3a-j was synthesized. The target compounds 3a-j were investigated for their potential antibacterial and antifungal activities. S. aureus, MRSA, E. faecalis, P. aeruginosa, K. pneumonia, and E. coli were used for testing the antibacterial activity, while Candida albicans and Aspergillus spp, were used for antifungal activity of the tested compounds. Compounds 3i and 3j exhibited the strongest activity, particularly against Gram-positive bacteria. Antifungal activity was tested against Aspergillus spp. and Candida albicans using the agar diffusion method, with a final concentration of 10,000 µg/mL per well. Eight compounds inhibited Aspergillus spp., while only compound 3g was active against C. albicans. Compound 3f displayed the highest antifun

SUBMITTER: Ezelarab HAA 

PROVIDER: S-EPMC12672562 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature