Application of pretreatment ¹⁸F-FDG PET metabolic parameters in children with Langerhans cell histiocytosis.

ABSTRACT: To evaluate whether pre-treatment ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) metabolic parameters can predict cfBRAF V600E mutation status and prognosis in pediatric Langerhans cell histiocytosis (LCH). We retrospectively analyzed 64 newly diagnosed pediatric LCH patients who underwent pre-treatment ¹⁸F-FDG PET/CT between September 2020 and March 2024. Metabolic parameters were measured, including maximum standardized uptake value (SUVmax), tumor-to-liver standardized uptake value ratio (SUVR_liver), tumor-to-bone marrow standardized uptake value ratio (SUVR_BM), total metabolic tumor volume (tMTV), and total lesion glycolysis (tTLG). Associations between metabolic parameters and cfBRAF V600E

SUBMITTER: Wen X 

PROVIDER: S-EPMC12672597 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature