Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.

ABSTRACT:

Introduction

This systematic review and meta-analysis aimed to evaluate the effects of exercise interventions on bone mineral density (BMD), bone mineral content (BMC), and bone turnover markers in patients with cancer and compromised bone health.

Materials and methods

A comprehensive search of four electronic databases was conducted to identify randomized controlled trials evaluating the effect of exercise intervention compared to supplementation or bone-targeted agents only on BMD, BMC and bone turnover markers. Meta-analyses were performed using random-effects models to calculate effect sizes (ES) with 95% confidence intervals (CI).

Results

Eighteen studies were included, involving 1,478 patients with mainly breast and prostate cancer. Meta-analyses of 11 trials sh

SUBMITTER: Borsati A 

PROVIDER: S-EPMC12672621 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature