Exploring the therapeutic effects of intensified immunosuppressive regimen for preengraftment syndrome after umbilical cord blood transplantation.

ABSTRACT: Preengraftment syndrome (PES) is a common complication of cord blood transplantation (CBT) that causes an inflammatory storm and organ impairments. Optimal treatment strategies for PES remain unclear.This study aims to explore the therapeutic effects of post-transplant cyclophosphamide (PTCy), etanercept, and methylprednisolone in the treatment of PES. This study included 60 patients who were diagnosed with PES after single umbilical cord blood transplantation between 2016 and 2023. Outcomes were compared between a historical control group (2016-2019, n = 27) treated with methylprednisolone and a cohort that received an intensified immunosuppressive regimen (2020-2023, n = 33) consisting of PTCy, etanercept, and methylprednisolone. The comparison encompassed key clinical outcomes, includin

SUBMITTER: Liu D 

PROVIDER: S-EPMC12672658 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature