Age interaction in associations between geriatric nutritional risk index and prognosis in diffuse large B-cell lymphoma.

ABSTRACT: To evaluate whether age modifies the association between the geriatric nutritional risk index (GNRI) and overall survival (OS) in patients aged ≥ 18 years with newly diagnosed diffuse large B-cell lymphoma (DLBCL), we conducted a multi-centre retrospective study of 552 patients. Multivariable Cox regression with restricted cubic spline (RCS) modelling showed that GNRI was significantly associated with OS, but the relationship was non-linear (P for non-linearity = 0.0158). A three-dimensional Cox-RCS model revealed that older age was associated with a higher mortality risk. The association between lower GNRI and worse OS was consistent across all age groups, including younger patients. Among patients with low GNRI (< 92), the most common pattern of malnutrition involved normal albumin (Alb)

SUBMITTER: Fujita K 

PROVIDER: S-EPMC12672688 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature