Synthesis and insecticidal activity of some pyrazole, pyridine, and pyrimidine candidates against Culex pipiens L. larvae.

ABSTRACT: The expansion of the Culex pipiens population has increased the spread of arboviruses, due to the ineffectiveness of several traditional insecticides available to control this vector. Some heterocycles bearing a benzoquinoline moiety, such as pyrazoline, pyridine, pyridone, and pyrimidine derivatives, were synthesized from the reaction of 3-(3-chlorobenzo[f]quinolin-2-yl)-1-(4-chlorophenyl)prop-2-en-1-one with some nitrogen and carbon nucleophiles. The synthesized compounds were investigated against laboratory and field strains of C. pipiens larvae. The activities of prepared derivatives were varied, where compounds 7, 5, and 9 showed good toxicities with LC₅₀ of 180.35, 222.87, and 235.25 µg/mL, respectively, for the lab strain. At the same time, their potencies decreased to 24

SUBMITTER: El-Helw EAE 

PROVIDER: S-EPMC12672691 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature