Clinical manifestations and outcomes of EBV-related secondary hemophagocytic lymphohistiocytosis.

ABSTRACT:

Aim

Epstein-Barr virus (EBV) is an important pathogen of infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is also a common cause of secondary hemophagocytic lymphohistiocytosis (sHLH). Thus, we aimed to identify the clinical manifestations and outcomes of EBV-related sHLH after allo-HSCT.

Methods

We enrolled the patients who experienced sHLH after EBV DNAemia after allo-HSCT from Jan 1st, 2023 to Dec 31st, 2023. Plasma EBV copies were monitored by Q-PCR analysis at least weekly, and EBV-DNA copies of lymphocyte subpopulations in peripheral blood were also quantified by Q-PCR.

Results

Eleven patients developed sHLH after EBV DNAemia, and all of them had post-transplant lymphoproliferative disorders (PTLD) before sHLH. The median tim

SUBMITTER: Liu D 

PROVIDER: S-EPMC12672808 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature