Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection.

ABSTRACT:

Purpose

While local immune responses in periprosthetic joint infection (PJI) are increasingly studied, systemic immune alterations remain poorly characterized. Therefore, this study aimed to investigate the change in peripheral lymphocyte subsets and immune-related protein profiles in patients with PJI, and explore the potential value of these indicators for the diagnosis of PJI.

Methods

Between July 2023 and January 2024, this prospective study recruited 82 patients who had been diagnosed with PJI or aseptic failure (AF), or who were healthy controls. Peripheral blood lymphocyte subpopulations and immune-related proteins were measured using flow cytometry or nephelometry and compared between groups. The diagnostic capability of different indicators for PJI was assessed. Bes

SUBMITTER: Li Z 

PROVIDER: S-EPMC12672869 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature