Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis.

ABSTRACT:

Background

Sepsis is associated with significant lipidomic disturbances, but age-associated lipidomic patterns remain poorly characterized. Given the links between aging, immune dysfunction, and metabolic dysregulation, defining age-specific lipid profiles could improve sepsis risk assessment. This study investigates age-stratified lipidomic signatures in sepsis and identifies biomarkers for clinical severity.

​methods

We prospectively enrolled 62 sepsis patients (21 <65 years, 41 ≥65 years) and 40 healthy controls. Plasma lipidomics was performed via untargeted LC-MS/MS, identifying 1,277 lipid species across 38 subclasses. Principal component analysis (PCA) and consensus clustering were used to assess lipidomic differences and define patient subtypes. Correlations between

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12672909 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature