Case Report: Severe kidney involvement in a case of very early onset inflammatory bowel disease.

ABSTRACT:

Background

Patients affected by very early onset inflammatory bowel disease (VEO-IBD) are frequently refractory to standard treatments. Despite the lack of randomized clinical trials, vedolizumab emerged as an effective and safe alternative treatment in VEO-IBD resistant to TNF antagonists. Here, we present a case of VEO-IBD with ulcerative colitis (UC) phenotype developing renal injury after vedolizumab administration.

Case presentation

An 11-year-old female patient with VEO-UC was referred to our clinic for fever, nausea, and fatigue. She was treated with vedolizumab for 1 year due to steroid-dependent disease and failure of multiple therapies, including anti-TNF agents. At admission, she was in steroid-free clinical and endoscopic remission, with leukocytosis, increased i

SUBMITTER: Drago E 

PROVIDER: S-EPMC12672911 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature