Epididymal epithelial cells facilitate NEU1 loading to modulate sperm α-2,6 sialylation, enhance maturation and motility.

ABSTRACT:

Background

Male infertility is a prevalent reproductive disorder worldwide, with decreased sperm quality-particularly reduced motility and fertilization capacity-being one of its common causes. Sperm maturation is a complex process involving multiple molecular mechanisms, the specific pathways regulating sperm motility remain unclear and require further investigation. Among these mechanisms, sialylation serves as an important glycosylation modification during sperm maturation and capacitation, playing a crucial role in these processes. Nonetheless, the specific function of Neuraminidase-1 (NEU1), a kind of sialidase, in sperm maturation and function remains poorly understood. This study aims to investigate the origin and function of NEU1 in sperm, as well as its impact on sperm mot

SUBMITTER: Yi S 

PROVIDER: S-EPMC12672989 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature