GPR35 mediates monocyte recruitment to the sites of Listeria monocytogenes infection.

ABSTRACT: Recruitment of Ly6C^hi monocytes to infection sites critically contributes to the clearance of microbial pathogens. However, the mechanism regulating their migration from the peripheral blood to the infected sites remains unresolved. In this study, we demonstrate that G protein-coupled receptor GPR35 is required for the entry of circulating Ly6C^hi monocytes into the sites of Listeria monocytogenes infection. Gpr35^-/- mice showed a decrease in Ly6C^hi monocyte recruitment to the cecum and colon after oral administration of L. monocytogenes. They also exhibited a reduction in Ly6C^hi monocytes in the liver and spleen upon intravenous infection. Mechanistically, GPR35 signaling enhanced Mac-1- and LFA-1-dependent Ly6C^hi monocyte a

SUBMITTER: Okamura Y 

PROVIDER: S-EPMC12673015 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature