Lactococcus lactis-HSP65 requires TLR2 to induce tolerogenic dendritic cells and confer protection against type 1 diabetes in a murine model.

ABSTRACT: Type 1 Diabetes (T1D) is characterized by the destruction of insulin-producing β cells, leading to hyperglycemia. New therapeutic strategies are crucial for preventing or managing the disease and its complications. Natural or recombinant probiotics, by modulating the gut microbiota and dictating the immunological tolerance, have been recently employed as tolerogenic immunotherapy for autoimmune diseases. Heat shock protein 65 (HSP65) exhibits regulatory and anti-inflammatory activity in autoimmune and chronic inflammatory conditions. Here, we show that dendritic cells from T1D patients exhibit reduced expression of immunological tolerance-associated genes and diminished TLR2 expression. Recombinant HSP65 (rHSP65) upregulated Tlr2 expression and promoted the differentiation of classical den

SUBMITTER: Elias-Oliveira J 

PROVIDER: S-EPMC12673016 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature