Three-dimensional distensibility of the aorta derived from four-dimensional cardiovascular magnetic resonance in young and middle-aged adults with Marfan syndrome.

ABSTRACT:

Background

Acute aortic syndromes in Marfan syndrome (MFS) often occur before reaching the surgical diameter threshold, highlighting the need for new imaging biomarkers.

Objectives

Aim was to compare cardiovascular magnetic resonance (CMR)-derived aortic three-dimensional (3D) distensibility and displacement in MFS patients with or without a history of aortic root surgery (RR or native) and healthy volunteers.

Methods

The participants underwent 3T CMR of the thoracic aorta using an accelerated non-contrast-enhanced, free breathing, 3D cine balanced steady state free precession sequence, with spatiotemporal resolution: (1.0 mm)³/∼33ms. A deep learning-based algorithm was used to obtain aorta segmentations. Non-rigid registration of these segmentations was su

SUBMITTER: Bosshardt D 

PROVIDER: S-EPMC12673023 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature