The effect of proton-pump inhibitor therapy on disease outcomes in inflammatory bowel disease: a population-based cohort study.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) use has been linked to adverse outcomes in patients with inflammatory bowel disease (IBD). However, it remains unknown whether this is due to protopathic bias (i.e., when the outcome precedes exposure).

Objectives

We aimed to conduct a propensity-weighted study of the association between PPI use and IBD-related hospitalizations and surgery in patients with IBD.

Design

Historical propensity score (PS)-weighted cohort study.

Methods

We identified all Danish residents diagnosed with IBD in 2000-2022 in the Danish National Patient Registry. We analyzed separate PPI treatment episodes allowing an individual to contribute with more than one PPI episode. We used PS-weighted Cox regression to estimate the hazard ratio (HR) for I

SUBMITTER: Deleuran T 

PROVIDER: S-EPMC12673057 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature