Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures.

ABSTRACT: Seizures are frequent complications in brain tumor patients, yet the underlying neuronal mechanisms remain poorly defined. Here, we examined pathophysiological alterations in the peritumoral cortex of patients undergoing tumor resection. The synaptic activity, dendritic spine density, and gene expression of peritumoral pyramidal neurons differed significantly between patients with and without seizures. Using an inducible glioma rodent model, we characterized the progression of these alterations and their predictive value for seizure initiation. Computational simulations revealed that human cortical neurons are highly susceptible to synaptic and dendritic perturbations, which induce paroxysmal depolarizing shifts (PDS) in affected networks. Longitudinal analyses post-surgery showed that PDS

SUBMITTER: Bouwen BLJ 

PROVIDER: S-EPMC12673072 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature