Single-cell transcriptomic analysis of the heterogeneity of mesenchymal and stromal cells and their regulon alteration during airway remodeling in asthma.

ABSTRACT: Mesenchymal stem/stromal cells (MSCs) have emerged as a promising therapeutic approach for immune-mediated diseases, including asthma, which is characterized by persistent airway inflammation and remodeling. Accumulating research evidence highlights the critical involvement of cellular heterogeneity in disease pathogenesis. In this study, we explored the heterogeneity of mesenchymal and stromal cell populations and their contribution to asthma pathogenesis by comprehensively analyzing single cell transcriptomic data from a cynomolgus monkey model of asthma. We have identified 10 stromal and 4 mesenchymal subpopulations, each with distinct functions and divergent responses to airway inflammation and remodeling. Under the disease state, regulons of FOXF1, ETS1, ETS2, GATA3 and RELB were sign

SUBMITTER: Chen X 

PROVIDER: S-EPMC12673086 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature