Computational biological analysis reveals that HIF-1 and FoxO signaling pathways influence cognitive impairment in patients with depression.

ABSTRACT: Cognitive impairment, a common symptom in patients with depression, significantly affects social functioning. Currently, no recognized treatment exists for depression-related cognitive dysfunction. The study aimed to use computational biology methods to investigate the potential molecular mechanisms underlying cognitive impairment in depression and identify potential antidepressants that may mitigate this impairment. Targets associated with depression and cognitive impairment were obtained from GeneCards and OMIM. Overlapping disease targets were integrated to generate a PPI network, and hub targets were identified using network topology metrics. KEGG pathway enrichment analyses were conducted using the DAVID database. Finally, core targets enriched in key signaling pathways were virtually

SUBMITTER: Zhuo C 

PROVIDER: S-EPMC12673102 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature