Characterizing white matter hyperintensities in myotonic dystrophy type 1 through IVIM derived metrics.

ABSTRACT: Myotonic dystrophy type 1 (DM1) is a genetic disease which affects multiple systems including the central nervous system. One of its key neuroimaging biomarkers are white matter hyperintensities (WMHs). The clinical relevance of WMHs remains unclear, and treating them as a uniform entity may overlook their heterogeneous composition and spatial distribution. To assess WMHs heterogeneity we applied intra-voxel incoherent motion (IVIM) modelling, an advanced magnetic resonance imaging technique, to a cohort of 23 patients with DM1 (age [mean ± std]: 44.1 ± 11.9 years; M/F = 8/15). WMHs were distinguished into periventricular (PWMHs) and deep (DWMHs) subtypes using criteria based on continuity and distance rules. A quantitative evaluation of their distribution among white matter tracts was con

SUBMITTER: Di Stefano M 

PROVIDER: S-EPMC12673117 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature