Impact of fluorine-containing nanoparticle PEGylation on inflammation imaging by ¹⁹F MRI.

ABSTRACT: Fluorine-containing nanoparticles (FNPs) are widely used for inflammation imaging by fluorine-19 magnetic resonance imaging (¹⁹F MRI) due to their biocompatibility and suitability to track immune cells via phagocytic uptake. For targeting approaches beyond passive incorporation, surface PEGylation of FNPs is required to reduce cellular uptake, but is known to prolong blood half-life of the particles. This study investigates the efficacy of FNP PEGylation for inflammation imaging in vivo. FNPs and PEGylated FNPs (^PEGFNPs) of different size were synthesized and characterized for particle properties and fluorine content. Cellular uptake was explored in CHO, RAW, and J774 cells as well as in whole blood using flow cytometry. For in vivo imaging, a murine lipopolysaccharid

SUBMITTER: Bouvain P 

PROVIDER: S-EPMC12673124 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature