Oroxylum indicum ameliorates D-galactose-induced aging related memory impairments via enhancing rat hippocampal neurogenesis.

ABSTRACT: Brain aging significantly affects human lives, particularly among the elderly, leading to various diseases and constituting memory and cognitive decline. Hippocampal neurogenesis, the process of generating new neurons throughout life, decline with aging, which contribute to cognitive decline and dementia. D-galactose (D-gal) induces brain aging by increasing oxidative stress and inflammation, resulting in neurodegeneration and memory dysfunction. Oroxylum indicum fruit extract (OIFE), a traditional Thai herb, possesses strong antioxidant and neuroprotective properties. We investigated whether OIFE extract mitigates D-gal-induced memory decline, assessing its phytochemical profile, antioxidant capacity and neuroprotective effects. The results revealed that OIFE possessed strong phytochemica

SUBMITTER: Tanrangka N 

PROVIDER: S-EPMC12673138 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature