MUC1 in Colorectal Carcinoma: Association With Prognosis and Putative Anoikis-Resistant Structures.

ABSTRACT: Mucin 1 (MUC1) is overexpressed in colorectal cancer (CRC), yet its prognostic value is controversial. In vitro, MUC1 promotes anoikis resistance. Putative anoikis-resistant (AR) structures are clusters of carcinoma cells surviving without matrix contact, and are associated with adverse prognosis. We explored the prognostic role of MUC1 in CRC and its association with putative AR structures. We studied 118 patients with CRC, including 52 with nodal metastases. Immunohistochemical MUC1 expression was analyzed in primary tumors and nodal metastases by estimating the proportions of MUC1-positive carcinoma cells within different subpopulations. In primary tumors, MUC1 expression was increased in most putative AR structure types, and abundant AR structures were associated with elevated MUC1. MU

SUBMITTER: Mattila TT 

PROVIDER: S-EPMC12673294 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature