Toll-Like Receptor Polymorphisms Influence Graft-Versus-Host Disease and Infection Risk After Single-Unit Cord Blood Transplantation for Adults.

ABSTRACT:

Background

Toll-like receptors (TLRs) play a critical role in innate immunity by recognizing pathogen-associated and damage-associated molecular patterns. Genetic polymorphisms in TLR genes can modulate immune responses and have been implicated in the outcomes of allogeneic hematopoietic cell transplantation (HCT). However, their impact on clinical outcomes after single-unit cord blood transplantation (CBT) remains unclear.

Methods

We retrospectively analyzed adult patients who underwent single-unit CBT at our institution between January 2005 and March 2023 with available recipient or donor DNA samples. Genotyping of TLR2 (rs3804099), TLR3 (rs3775291), TLR5 (rs5744174), and TLR9 (rs352140) was performed. Associations between recipient and donor TLR polymorphisms and transpla

SUBMITTER: Konuma T 

PROVIDER: S-EPMC12673356 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature