Correlation between insulin receptor expression and tumor cell proliferation, recurrence and metastasis in well-differentiated pancreatic neuroendocrine neoplasms.

ABSTRACT:

Objective

To investigate the correlation between insulin receptor (IR) expression and patients' preoperative blood glucose level, and to analyze the correlation between IR expression level (IR percentage) and well-differentiated pancreatic neuroendocrine neoplasms (pNENs) cell proliferation and recurrence, and to explore whether it can be used as a potential biomarker for predicting tumor recurrence and metastasis.

Methods

A retrospective evaluation of the clinical data of 81 patients with well-differentiated pNENs who underwent surgical treatment at five different centers between January 2015 and September 2024 was performed. A subset of patients' pathological sections was collected for analysis.

Results

Multivariate linear regression analysis revealed that blood glu

SUBMITTER: Deng X 

PROVIDER: S-EPMC12673363 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature