Frontotemporal dementia characterization using neurite orientation dispersion and density imaging.

ABSTRACT: Microstructural alterations in brain tissue play a crucial role in the pathophysiology of frontotemporal dementia (FTD). This study assessed brain white matter (WM) and grey-matter (GM) microstructure in FTD variants using neurite orientation dispersion and density imaging (NODDI) diffusion MRI model and developed an exploratory machine-learning algorithm to classify FTD subtypes according to diffusion MRI metrics. Brain MRI including multi-shell diffusion sequences and neuropsychological assessment were obtained in controls and participants with FTD: 35 behavioural variant of FTD (bvFTD), 20 semantic-variant primary progressive aphasia (svPPA), 14 nonfluent-variant primary progressive aphasia (nfvPPA), 9 semantic-bvFTD (sbvFTD). Fractional anisotropy (FA), mean diffusivity (MD), intracell

SUBMITTER: Pisano S 

PROVIDER: S-EPMC12673379 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature