Decision-Making and Downstream Outcomes of the Gabapentinoid-Diuretic Prescribing Cascade.

ABSTRACT:

Importance

Prescribing cascades are an underrecognized driver of polypharmacy among older adults (aged ≥65 years). The clinical decision-making processes underlying cascades and their downstream consequences are poorly understood.

Objective

To explore clinical reasoning leading to prescribing cascades and downstream outcomes (eg, falls, electrolyte abnormalities) via the exemplar gabapentinoid (gabapentin and pregabalin)-loop diuretic (LD) cascade.

Design, setting, and participants

This cohort study randomly selected medical records from a cohort of US veterans aged 66 years or older between January 1, 2013, and August 31, 2019, who potentially experienced the gabapentinoid-LD prescribing cascade. The medical record review and data analysis were performed between Octo

SUBMITTER: Growdon ME 

PROVIDER: S-EPMC12673415 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature