Importance of targeting post-prandial hyperglycaemia to achieve HbA1c goals in insulin glargine-treated subphenotypes of type 2 diabetes.

ABSTRACT:

Aims

To explore outcome parameters related to achieving HbA1c goal (<7.0%) in subphenotypes of type 2 diabetes (T2D), either on basal insulin (BI) glargine 300 U/mL or 100 U/mL or switched to these BIs (≥42 U/day) alone or with pre-prandial insulin.

Materials and methods

Participants from three EDITION T2D trials (n = 2,435) were clustered into T2D subphenotypes, with ≥97% having either Severe Insulin-Deficient Diabetes (SIDD) (9%-22%), Mild Age-Related Diabetes (MARD) (8%-18%), or Mild Obesity Diabetes (MOD) (56%-78%) across trials. Subphenotypes were stratified by HbA1c goal achievement (HbA1c <7.0%/responders or ≥7.0%/non-responders), and efficacy and safety parameters were analysed both at baseline and after 26 weeks. Glargine groups were pooled.

Results

With all

SUBMITTER: Landgraf W 

PROVIDER: S-EPMC12673423 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature