Progressive increases in adiposity and ectopic fat surrogates across glycaemic states highlight weight reduction as a key target for type 2 diabetes prevention, especially in younger people.

ABSTRACT:

Aims

To determine whether there are progressive changes in weight and ectopic fat surrogates in individuals comparing normoglycaemia, prediabetes and undiagnosed type 2 diabetes, and whether these increments differ by age.

Materials and methods

Cross-sectional analysis of UK Biobank White participants without baseline cardiovascular disease or known diabetes (n = 287 987). Participants were classified based on glycated haemoglobin (HbA1c): normal (<5.7% [38.9 mmol/mol]), prediabetes1 (5.7-5.9% [39.0-41.9 mmol/mol]), prediabetes2 (6%-6.2% [42.0-44.9 mmol/mol]), prediabetes3 (6.3%-6.4% [45-47.9 mmol/mol]) and undiagnosed diabetes (6.5%-9% [48-75 mmol/mol]). Ordered logistic and linear regressions were used to test associations between HbA1c groups and differences in body mass

SUBMITTER: Scilletta S 

PROVIDER: S-EPMC12673443 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature