Psychiatric effects of GLP-1 receptor agonists: A systematic review of emerging evidence.

ABSTRACT: This systematic review examines the current literature on glucagon-like peptide-1 receptor agonists (GLP-1RAs)-associated psychiatric manifestations, including depression, suicidality, eating disorders, substance use disorders (SUD) and schizophrenia spectrum disorders. A comprehensive literature search was conducted to identify studies evaluating the association between GLP-1RAs and psychiatric outcomes. The electronic databases systematically searched were PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Embase and Web of Science. GLP-1RAs are increasingly recognised for their potential neuropsychiatric effects beyond glycaemic control and weight loss. Findings suggest modest antidepressant effects, inconsistent associations with suicidality and potential therapeutic benef

SUBMITTER: Sa B 

PROVIDER: S-EPMC12673456 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature