Digital engagement enhances dual GIP/GLP-1 receptor agonist and GLP-1 receptor agonist efficacy: A retrospective cohort analysis of a digital weight loss service on outcomes and safety.

ABSTRACT:

Aims

We evaluated the weight loss efficacy and safety of a national digital weight loss service (DWLS) and explored associations between digital engagement and outcomes in adults prescribed dual GIP/GLP-1RA and GLP-1RA.

Materials and methods

We conducted a retrospective longitudinal cohort analysis of adults prescribed dual GIP/GLP-1RA and GLP-1RA between August 2024 and July 2025 within the Voy DWLS in the United Kingdom (UK). Digitally engaged patients met all three criteria: (i) ≥1 coaching session; (ii) weekly weight logging (≥4/month); and (iii) ≥1 additional in-app interaction. Weight-loss trajectories were modelled using mixed models for repeated measures (MMRM). Kaplan-Meier methods and Cox models examined time to attain weight loss thresholds (≥5, ≥10, ≥15, ≥20, ≥25

SUBMITTER: Johnson H 

PROVIDER: S-EPMC12673462 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature