Percutaneous Coronary Interventions for Calcified Lesions: A Systematic Review with Meta-analyses of Randomised Trials.

ABSTRACT:

Background

Coronary arterial calcification impedes safe and predictable percutaneous coronary intervention (PCI), and guidelines recommend calcium modification. Several interventional techniques exist, but the most optimal technique remains unclear. The aim of this study was therefore to assess the effects of PCI strategies for calcified lesions on all-cause mortality and serious adverse events.

Methods

A systematic review with meta-analysis and trial sequential analysis of randomised trials was conducted to compare any lesion preparation or stenting technique in patients undergoing PCI for moderately or severely calcified coronary lesions according to a published protocol. CENTRAL, MEDLINE, Embase and other sources were searched up to 8 May 2025.

Results

Out of 7,172

SUBMITTER: Kristensen AT 

PROVIDER: S-EPMC12673492 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature