Decoding Immune Influence: A Mendelian Randomisation Study on Dilated Cardiomyopathy.

ABSTRACT:

Background

Dilated cardiomyopathy (DCM) is a significant contributor to heart failure, originating from complex interactions between genetic and environmental factors. Although the immune system has been implicated in various cardiovascular diseases, its precise role in DCM pathogenesis remains ambiguous. This study uses Mendelian randomisation (MR) to explore the causal relationship between diverse immune cell traits and DCM risk.

Methods

We conducted a two-sample MR analysis using summary-level data from genome-wide association studies of 731 immune cell traits and DCM. Our primary method employed fixed- and random-effects inverse-variance weighting, complemented by sensitivity analyses - such as MR-Egger, Mendelian Randomisation-Pleiotropy RESidual Sum and Outlier (MR-PRE

SUBMITTER: Gao W 

PROVIDER: S-EPMC12673495 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature