In utero exposure to anti-Caspr2 antibody disrupts parvalbumin interneuron function in the hippocampus.

ABSTRACT: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in communication and social interaction and may stem from an imbalance between excitatory and inhibitory (E/I) signaling in neural circuits. Parvalbumin-expressing (PV+) interneurons are crucial for maintaining E/I balance and regulating network oscillations. Alterations in the number of PV+ interneurons or reductions in PV expression have been observed in both the postmortem brains of individuals with ASD and in animal models, including those induced by in utero exposure to maternal brain-reactive antibodies. In this study, we investigate the impact of in utero exposure to maternal anti-Caspr2 IgG on PV+ interneuron development and function in the hippocampus. Our results demonstrate a selec

SUBMITTER: Bagnall-Moreau C 

PROVIDER: S-EPMC12673504 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature