Ultrasensitive and Tunable Achiral Metamaterial Substrates as Nanobiosensors for Enantiomer Detection.

ABSTRACT: Distinguishing the chirality of biomolecules is of fundamental importance in biophysics and pharmaceutics. Circular dichroism (CD) spectroscopy provides a noninvasive approach to distinguish right- and left-handed enantiomers and can offer valuable insight into the structure of the investigated molecules. However, the intrinsic CD signal of biomolecules is often weak and typically resides in the ultraviolet spectral range, for which optical components are costly. Therefore, a tunable platform that boosts the CD signal of analytes in the optimal spectral range for the desired application would be an ideal solution. We combine tilted plasmonic nanohole arrays with ultrathin photonic cavities in our metamaterial substrates to achieve very high CD signal enhancement. In this approach, the spec

SUBMITTER: Mirahmadi M 

PROVIDER: S-EPMC12673517 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature