Association of respiratory symptom profiles with future exacerbations and lung function decline in mild-to-moderate COPD.

ABSTRACT:

Background

The prognostic value of respiratory symptom profiles for predicting exacerbation risk and lung function decline remains unclear in mild-to-moderate chronic obstructive pulmonary disease (COPD).

Research question

Are respiratory symptom profiles associated with both exacerbation risk and lung function decline in mild-to-moderate COPD?

Study design and methods

This was a posthoc analysis of data from participants with mild-to-moderate COPD from the SubPopulations and InteRmediate Outcome Measures in COPD Study. Respiratory symptom profiles were identified through latent class analysis. Outcomes included exacerbation rates evaluated by zero-inflated negative binomial regressions, time-to-first exacerbation evaluated by Cox regression and longitudinal forced ex

SUBMITTER: Yang H 

PROVIDER: S-EPMC12673541 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature