Spatiotemporal dynamics of T cells in peripheral blood and tumor underlying differential responses to neoadjuvant PD-1 blockade in hepatocellular carcinoma.

ABSTRACT:

Background

Programmed cell death protein-1 (PD-1) blockade has shown promising clinical efficacy in hepatocellular carcinoma (HCC), yet the underlying immunological mechanisms governing response and resistance remain unclear. This study aimed to delineate the temporal and spatial dynamics of T-cell clonotypes and their relationship with pathological response in neoadjuvant PD-1 blockade therapy in HCC. By integrating T-cell receptor (TCR) repertoire analysis with transcriptomic profiling, we sought to elucidate the immune landscape alterations associated with treatment outcomes.

Methods

We analyzed longitudinal, matched tumor and blood samples from our previous clinical trial (NCT05471674), encompassing 114 specimens, including pre-nivolumab tumor biopsies, post-treatment re

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12673557 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature