A Redox-Active Hydrogen Bond Acceptor Enables Ligand Exchange in a Zinc Complex.

ABSTRACT: A zinc complex featuring a redox-active hydrogen bond acceptor, ferrocenecarboxylate, was designed to probe how the hydrogen bond strength could influence ligand binding at the metal. Oxidation of the redox-active hydrogen bond acceptor enabled facile ligand substitution with trifluoromethanesulfonate. Control studies confirmed that no substitution was possible without oxidation and that hydrogen bonding interactions were a necessary component for substitution to occur. Importantly, redox-tuning of the hydrogen bond acceptor can be achieved at a mild redox potential.

SUBMITTER: Gilchrist CN 

PROVIDER: S-EPMC12673585 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature