Complement system activation in wild boar (<i>Sus scrofa</i>) following parenteral administration of heat-inactivated <i>Mycobacterium bovis</i>.

ABSTRACT:

Introduction

Development of vaccines to preserve and improve human and animal health requires effective protective antigens, delivery platforms, and adjuvants. The immunostimulant based on heat-inactivated Mycobacterium bovis (IV) was developed to boost protective immune response in different animal species against pathogen infection and tick infestations.

Methods

In this study, a serum proteomics approach was used with functional annotations and enrichment network analysis for the characterization of immune pathways and biomarkers associated with parenteral administration of one, two, or three IV doses in the wild boar (Sus scrofa) animal model. An independent False Discovery Rate (FDR) analysis with the target-decoy approach provided by ProteinPilot™ was used

SUBMITTER: Villar M 

PROVIDER: S-EPMC12673616 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature